1903 On Opening Day, before 8,376 fans at Huntington Ave Baseball Grounds, the Americans defeat the A’s in the morning game of Patriot’s Day twin bill, 9–4.Connie Mack’s Athletics win the matinee match-up featuring two future Hall of Fame hurlers, 10–7, as 27,658 spectators enjoy watching starters Eddie Plank and Cy Young oppose one another.

1910 Indian Addie Joss throws his second career no-hitter beating the White Sox, 1-0.

1912 After two days of rain, the first game ever is finally played at Fenway Park with a comeback eleven-inning Red Sox win over the New York Highlanders, 7-6.

1912 In Detroit, the Tigers play their first game in Tiger Stadium defeating the Indians, 6-5.

1916 In Chicago, the Cubs play their first game at Weeghman Park beating the Reds in 11 innings, 7-6. The ballpark will be renamed Wrigley Field in 1926.

1920 Phillies player-manager Gavvy Cravath pinch hits a three-run homer beating the Giants, 3-0. It will his last major league home run.

1939 In his first major league at-bat, Red Sox 20-year old rookie Ted Williams strikes out against Red Ruffing of the Yankees. The 6-4 skinny ‘Kid’, who won the Triple Crown last season in the American Association, will finish the day 1-for-4 with his first hit of 2654 during in his 19-year career being a 400-foot double in a 2-0 loss at Yankee Stadium.

1946 The Cubs are shut out by Cardinal southpaw Harry Brecheen in their home opener at Wrigley Field, 2-0. The game is the first in the club’s history be televised as ‘Whispering’ Joe Wilson does the play-by-play for WBKB.

1967 Mets’ rookie hurler Tom Seaver gets his first major-league win as New York beat the Cubs, 6-1. ‘Tom Terrific’ goes 7 2/3 innings giving up eight hits and one run.

1968 Jon Warden, the last man to make the team in spring training, makes his third appearance, and wins for the third time in relief, as Detroit beats the White Sox at Comiskey Park in 10 innings, 4-1. Due to a torn rotator cuff injury after being selected by the Royals in the expansion draft, the rookie sensation, who will be the only Tiger not to appear in the World Series, will pitch only one season finishing with a 4-1 win-loss record and a 3.62 ERA

1973
Four months after his death, Pirate great Roberto Clemente in a special election is inducted into the Hall of Fame .

1982 With a 4-2 win over the Reds, the Braves record their 12th consecutive victory to establish a major-league record for the most victories from the beginning of the season. The previous mark had been set a year earlier by the Oakland A’s.

1985 In South Meriden, Connecticut Little League action, Matt Panetta’s timely hitting and outstanding defensive play helps Katz defeat MIC, 6-2. The 11-year old is awarded the game ball as a result of his efforts.

1988 The Orioles set major league record for consecutive losses at the start of a season losing #14 to the Brewers, 8-6. The 1904 Senators and 1920 Tigers had previously shared the mark with 13.

1988 Claudell Washington hits the 10,000th home run in Yankee history.

1990 After retiring 26 consecutive A’s player, Mariner Brian Holman gives up a homer to Ken Phelps.

1997 In the second game of a doubleheader, the Cubs stop their season-opening losing skid at 14 games beating the Mets, 4-3. By losing the opener, Chicago set a National League record (0-13) for the most consecutive losses to start a season and has the second-worst record behind the Baltimore Orioles who lost 21 decisions before winning a game in 1988.

1997 Mark McGwire becomes the fourth major leaguer to hit a home run over the left field roof at Tiger Stadium. The A’s first baseman joins Harmon Killebrew (1962), Frank Howard (1968), and Cecil Fielder (1990) as the only players to accomplish the feat.